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PRKRA antibody - middle region (ARP40475_P050)

100 ul
$289.00
In Stock

Conjugation Options

ARP40475_P050-FITC Conjugated

ARP40475_P050-HRP Conjugated

ARP40475_P050-Biotin Conjugated

Gene Symbol:
PRKRA
NCBI Gene Id:
8575
Official Gene Full Name:
Protein kinase, interferon-inducible double stranded RNA dependent activator
Protein Name:
Interferon-inducible double stranded RNA-dependent protein kinase activator A
Swissprot Id:
O75569
Protein Accession #:
NP_003681
Nucleotide Accession #:
NM_003690
Alias Symbols:
RAX, PACT, DYT16, HSD14
Replacement Item:
This antibody may replace item sc-63342 from Santa Cruz Biotechnology.
Description of Target:
PRKRA contains 3 DRBM (double-stranded RNA-binding) domains. It appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor and activates EIF2AK2 in absence of double stranded RNA (dsRNA).
Protein Size (# AA):
313
Molecular Weight:
34kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PRKRA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PRKRA.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human PRKRA
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Complete computational species homology data:
Anti-PRKRA (ARP40475_P050)
Peptide Sequence:
Synthetic peptide located within the following region: RLPEYTLSQEGGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLA
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
ZMAT3; PRKRA; TARBP2; LYAR; STAU1; UBC; H1F0; EIF2AK2; CCDC124; C1orf35; DDX50; NOC3L; NOP16; STAU2; ZNF346; GTPBP4; DICER1; RBM34; EBNA1BP2; IFRD2; TCOF1; BMI1; SRPK3; POLR2G; MDC1; CAND1; UBE2I; SIRT7; ZFP28; KIAA1377; NKRF; SNX5; RABEPK; CEBPZ; SHC1; Z
Blocking Peptide:
For anti-PRKRA (ARP40475_P050) antibody is Catalog # AAP40475 (Previous Catalog # AAPP22243)
Datasheets/Manuals:
Printable datasheet for anti-PRKRA (ARP40475_P050) antibody
Sample Type Confirmation:

PRKRA is supported by BioGPS gene expression data to be expressed in Jurkat

Target Reference:
Lee,Y., (2006) EMBO J. 25 (3), 522-532
Publications:

Yoshida, K. et al. Interaction between PKR and PACT mediated by LPS-inducible NF-κB in human gingival cells. J. Cell. Biochem. 113, 165-73 (2012). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat 21882225

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