PRKAG3 Antibody (OABF01376)

Catalog No: OABF01376

Size:100ul

Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-AMPK gamma 3/PRKAG3 Polyclonal Antibody, Unconjugated (OABF01376) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: WB, IHC-P
• Additional Information: Subcellular location:
• Reconstitution and Storage: Store at -20C for 12 months.
• Immunogen: KLH conjugated synthetic peptide derived from human AMPK gamma 3
• Purification: Purified by Protein A.
• Concentration: 1ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: PRKAG3
• Gene Full Name: protein kinase, AMP-activated, gamma 3 non-catalytic subunit
• Alias Symbols: AMPKG3, SMGMQTL
• NCBI Gene Id: 53632
• Description of Target: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
• Uniprot ID: Q9UGI9