PRKACB Antibody (OABF00178)

Catalog No: OABF00178

Size:100UL

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-PKA/PKAcat/PKACB Polyclonal Antibody, Unconjugated (OABF00178) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location: Cytoplasm
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from bovine PKA
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: PRKACB
• Gene Full Name: protein kinase cAMP-activated catalytic subunit beta
• Alias Symbols: cAMP-dependent protein kinase catalytic subunit beta;PKA C-beta;protein kinase, cAMP-dependent, catalytic, beta.
• NCBI Gene Id: 282323
• Protein Name: cAMP-dependent protein kinase catalytic subunit beta
• Description of Target: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA.
• Uniprot ID: P05131