Size:100 ug
$269.00
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SKU
OABB00317
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Presenilin-2 Polyclonal Antibody (OABB00317)

Catalog#: OABB00317
Domestic: within 1 week delivery | International: 1 week
This product is Genway GWB-BBP239
More Information
Predicted Species Reactivity Human, Mouse, Rat
Product Format Lyophilized
Clonality Polyclonal
Application WB, IHC-P, IHC-F
Additional Information Content: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
:: Background: Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene.[1]Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.[2]
Reconstitution and Storage 0.2ml of distilled water will yield a concentration of 500ug/ml. At -20C for one year. After reconstitution, at 4C for one month. It can
also be aliquotted and stored frozen at -20C for a longer time.
Avoid repeated freezing and thawing.
Replacement Item This antibody may replace item sc-1456 from Santa Cruz Biotechnology.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human Presenilin-2, different from the related mouse and rat sequences by two amino acids.
Purification Immunogen affinity purified.
Predicted Homology Based on Immunogen Sequence Human; Mouse; Rat
Datasheets/Manuals Printable datasheet for OABB00317
Specificity Rabbit IgG
Target Reference 1. Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, Bird TD, Schellenberg GD (September 1995). "A familial Alzheimer's disease locus on chromosome 1".
2. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy".
Gene Symbol Psen2
NCBI Gene Id 81751
Protein Name Presenilin-2
Swissprot Id O88777
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express Psen2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express Psen2.
  1. What is the species homology for "Presenilin-2 Polyclonal Antibody (OABB00317)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "Presenilin-2 Polyclonal Antibody (OABB00317)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "Presenilin-2 Polyclonal Antibody (OABB00317)" provided in?

    This item is provided in "Lyophilized".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Presenilin-2 Polyclonal Antibody (OABB00317)"?

    This target may also be called "" in publications.

  5. What is the shipping cost for "Presenilin-2 Polyclonal Antibody (OABB00317)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Presenilin-2 Polyclonal Antibody (OABB00317)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Presenilin-2 Polyclonal Antibody (OABB00317)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Presenilin-2 Polyclonal Antibody (OABB00317)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "PSEN2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PSEN2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PSEN2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PSEN2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PSEN2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PSEN2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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