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Presenilin-2 Polyclonal Antibody (OABB00317)

100 ug
$375.00
In Stock
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Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Lyophilized
Clonality:
Polyclonal
Application:
WB, IHC-P, IHC-F
Additional Information:
Content: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
:::
Background: Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene.[1]Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.[2]
Reconstitution and Storage:
0.2ml of distilled water will yield a concentration of 500ug/ml. At -20C for one year. After reconstitution, at 4C for one month. It can
also be aliquotted and stored frozen at -20C for a longer time.
Avoid repeated freezing and thawing.
Gene Symbol:
Psen2
NCBI Gene Id:
81751
Protein Name:
Presenilin-2
Swissprot Id:
O88777
Replacement Item:
This antibody may replace item sc-1456 from Santa Cruz Biotechnology.
Purification:
Immunogen affinity purified.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express Psen2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express Psen2.
Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminal of human Presenilin-2, different from the related mouse and rat sequences by two amino acids.
Predicted Homology Based on Immunogen Sequence:
Human; Mouse; Rat
Datasheets/Manuals:
Printable datasheet for OABB00317
Specificity:
Rabbit IgG
Target Reference:
1. Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, Bird TD, Schellenberg GD (September 1995). "A familial Alzheimer's disease locus on chromosome 1".
2. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy".

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