Catalog No: OOMC00070
Price: $0.00
SKU
OOMC00070
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Datasheets/Manuals | Printable datasheet for OOMC00070 |
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Product Format | Powder |
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Additional Information | CAS: 138847-85-5 Molecular Formula: C19H27NO3 - HCl |
:: | Chemical Name: 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride |
:: | Primary Activity: Ion channel: Sigma-1 antagonist (Selective) |
:: | COVID-19 Rationale: Sigma 1 receptor agonist (SARS-CoV-2 Nsp6 protein interacts with the Sigma receptor) |
Reconstitution and Storage | Soluble in DMSO (up to 25 mg/ml) or in Water (up to 7 mg/ml). Store at -20C. |
Purity | > 98% |
Reference | 1) Su et al. (1991), Sigma compounds derived from phencyclidine. Identification of PRE-084, a new selective sigma ligand; J.Pharmacol.Exp.Ther. 259 543 2) Griesmaier et al. (2012), Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice; Exp.Neurol. 237 388 3) Dong et al. (2016), Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury; Cell Mol.Neurobiol. 36 639 4) Guzman-Lenis et al. (2009), Selective sigma receptor agonist 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons; Neuroscience 162 31 5) Hyrskyluoto et al. (2013), Sigma-1 receptor agonist PRE084 in protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-kB pathway; Cell Death Dis. 4 e646 6) Francardo et al. (2014), Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism; Brain 137(Pt7) 1998 7) Mancuso et al. (2012), Sigma-1R agonist improves motor function and motoneuron survival in ALS mice; Neurotherapeutics 9 814 |
Molecular Weight | 353.89 g/mol |
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- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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