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Catalog No: OOMC00070
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OOMC00070
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Datasheets/ManualsPrintable datasheet for OOMC00070
Product Info
Product FormatPowder
Additional InformationCAS: 138847-85-5
Molecular Formula: C19H27NO3 - HCl
::Chemical Name: 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride
::Primary Activity: Ion channel: Sigma-1 antagonist (Selective)
::COVID-19 Rationale: Sigma 1 receptor agonist (SARS-CoV-2 Nsp6 protein interacts with the Sigma receptor)
Reconstitution and StorageSoluble in DMSO (up to 25 mg/ml) or in Water (up to 7 mg/ml). Store at -20C.
Purity> 98%
Reference1) Su et al. (1991), Sigma compounds derived from phencyclidine. Identification of PRE-084, a new selective sigma ligand; J.Pharmacol.Exp.Ther. 259 543 2) Griesmaier et al. (2012), Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice; Exp.Neurol. 237 388 3) Dong et al. (2016), Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury; Cell Mol.Neurobiol. 36 639 4) Guzman-Lenis et al. (2009), Selective sigma receptor agonist 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons; Neuroscience 162 31 5) Hyrskyluoto et al. (2013), Sigma-1 receptor agonist PRE084 in protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-kB pathway; Cell Death Dis. 4 e646 6) Francardo et al. (2014), Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism; Brain 137(Pt7) 1998 7) Mancuso et al. (2012), Sigma-1R agonist improves motor function and motoneuron survival in ALS mice; Neurotherapeutics 9 814
Molecular Weight353.89 g/mol
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