PRDX3 Antibody - N-terminal region : Biotin (ARP52341_P050-Biotin)

Catalog No: ARP52341_P050-Biotin

Size:100ul

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Biotin
• Application: IHC, WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRDX3
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%
• Peptide Sequence: Synthetic peptide located within the following region: AIPWGISATAALRPAACGRTSLTNLLCSGSSQAPYFKGTAVVNGEFKDLS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-PRDX3 (ARP52341_P050-Biotin) antibody is Catalog # AAP52341 (Previous Catalog # AAPS30806)
• Sample Type Confirmation:

  PRDX3 is supported by BioGPS gene expression data to be expressed in Jurkat

• Reference: Chiribau,C.B., (2008) J. Biol. Chem. 283 (13), 8211-8217

Target Info

• Gene Symbol: PRDX3
• Gene Full Name: Peroxiredoxin 3
• Alias Symbols: AOP1, MER5, AOP-1, SP-22, HBC189, PRO1748, prx-III
• NCBI Gene Id: 10935
• Protein Name: Thioredoxin-dependent peroxide reductase, mitochondrial
• Description of Target: PRDX3 is a protein with antioxidant function and is localized in the mitochondrion. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.
• Uniprot ID: P30048
• Protein Accession #: NP_054817
• Nucleotide Accession #: NM_014098
• Protein Size (# AA): 238
• Molecular Weight: 26kDa
• Protein Interactions: GORASP2; SUMO1; NEDD8; MDM2; ARMCX3; NUSAP1; LNPEP; HNRNPD; NEK6; CDK2; UBC; TNFRSF1A; ITGA4; FN1; RPS6KC1; PRDX3; PRDX4; VCAM1; RNASET2; PSME1; PFKL; SPEN; UBQLN4; DCUN1D1; COPS5; CUL1; CUL2; CUL3; CUL4B; CUL5; SUMO4; MAPK3; NLRX1; HDAC5; UCHL5; H2AFX; T