PRDM14 Recombinant Protein (OPCD06371)

Catalog No: OPCD06371

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Glu395-His568
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: PRDM14
• Gene Full Name: PR/SET domain 14
• Alias Symbols: PFM11;PR domain 14;PR domain zinc finger protein 14;PR domain-containing 14;PR domain-containing protein 14.
• NCBI Gene Id: 63978
• Protein Name: PR domain zinc finger protein 14
• Description of Target: Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.
• Uniprot ID: Q9GZV8
• Protein Accession #: NP_078780.1
• Nucleotide Accession #: NM_024504.3
• Protein Size (# AA): Glu395~His568
• Molecular Weight: 49kDa