PRDM1 Recombinant Protein (OPCD06369)

Catalog No: OPCD06369

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Leu29-Asp149
  Subcellular Location: Nucleus, Cytoplasm
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: PRDM1
• Gene Full Name: PR/SET domain 1
• Alias Symbols: Beta-interferon gene positive regulatory domain I-binding factor;beta-interferon gene positive-regulatory domain I binding factor;BLIMP1;BLIMP-1;B-lymphocyte-induced maturation protein 1;Positive regulatory domain I-binding factor 1;PR domain 1;PR domain containing 1, with ZNF domain;PR domain zinc finger protein 1;PR domain-containing protein 1;PRDI-BF1;PRDI-binding factor-1.
• NCBI Gene Id: 639
• Protein Name: PR domain zinc finger protein 1
• Description of Target: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).
• Uniprot ID: O75626
• Protein Accession #: NP_001189.2
• Nucleotide Accession #: NM_001198.3
• Protein Size (# AA): Leu29~Asp149
• Molecular Weight: 21kDa