Catalog No: ARP42061_P050
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ARP42061_P050
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Datasheets/ManualsPrintable datasheet for anti-PPL (ARP42061_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Pig
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human PPL
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceHuman: 100%; Pig: 82%
Peptide SequenceSynthetic peptide located within the following region: EKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSF
Concentration0.5 mg/ml
Blocking PeptideFor anti-PPL (ARP42061_P050) antibody is Catalog # AAP42061 (Previous Catalog # AAPP24540)
Sample Type Confirmation

PPL is supported by BioGPS gene expression data to be expressed in MCF7

ReferenceBoczonadi,V., (2007) Exp. Cell Res. 313 (16), 3579-3591
Gene SymbolPPL
Gene Full NamePeriplakin
Alias SymbolsKIAA0568, MGC134872
NCBI Gene Id5493
Protein NamePeriplakin
Description of TargetPPL is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Uniprot IDO60437
Protein Accession #NP_002696
Nucleotide Accession #NM_002705
Protein Size (# AA)1756
Molecular Weight205kDa
Protein InteractionsCEP57L1; ZSCAN1; RAB3IP; TSC22D4; RALBP1; AHCYL1; VIM; TRAF2; TRIM27; ALAS1; AKT1; SKIL; UBC; USP7; CUL1; ITSN1; Cdk1; KAZN; PPHLN1; EVPL; CASP6; OPRM1; COL17A1; KRT8; EZR;
  1. What is the species homology for "PPL Antibody - middle region (ARP42061_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Pig".

  2. How long will it take to receive "PPL Antibody - middle region (ARP42061_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "PPL Antibody - middle region (ARP42061_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "PPL Antibody - middle region (ARP42061_P050)"?

    This target may also be called "KIAA0568, MGC134872" in publications.

  5. What is the shipping cost for "PPL Antibody - middle region (ARP42061_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "PPL Antibody - middle region (ARP42061_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "PPL Antibody - middle region (ARP42061_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "205kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "PPL Antibody - middle region (ARP42061_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "PPL"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PPL"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PPL"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PPL"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PPL"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PPL"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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