PPARGC1A Recombinant Protein (OPCD06342)

Catalog No: OPCD06342

PPARGC1A Recombinant Protein (OPCD06342) using SDS-PAGE

PPARGC1A Recombinant Protein (OPCD06342) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser573-Asn767
  Subcellular Location: Nucleus
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: PPARGC1A
• Gene Full Name: PPARG coactivator 1 alpha
• Alias Symbols: LEM6;Ligand effect modulator 6;ligand effect modulator-6;L-PGC-1alpha;peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext;peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a;peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT;peroxisome proliferator-activated receptor gamma coactivator 1-alpha;PGC1;PGC-1(alpha);PGC1A;PGC-1alpha;PGC-1-alpha;PGC-1v;PPAR gamma coactivator variant form;PPARgamma coactivator 1alpha;PPARGC1;PPARGC-1-alpha.
• NCBI Gene Id: 10891
• Protein Name: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
• Description of Target: Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.
• Uniprot ID: Q9UBK2
• Protein Accession #: NP_037393.1
• Nucleotide Accession #: NM_013261.3
• Protein Size (# AA): Ser573~Asn767
• Molecular Weight: 25kDa