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Catalog No: OPCD06341
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OPCD06341
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Datasheets/ManualsPrintable datasheet for PPARGC1A Recombinant Protein (OPCD06341)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Cys577-Asn766
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolPpargc1a
Gene Full Nameperoxisome proliferative activated receptor, gamma, coactivator 1 alpha
Alias SymbolsA830037N07Rik;Gm11133;peroxisome proliferator-activated receptor gamma coactivator 1-alpha;Pgc;Pgc1;PGC-1;Pgc-1alpha;Pgco1;PPAR-gamma coactivator 1-alpha;Ppargc1;PPARGC-1-alpha.
NCBI Gene Id19017
Protein NamePeroxisome proliferator-activated receptor gamma coactivator 1-alpha
Description of TargetTranscriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. Isoform 4 specifically activates the expression of IGF1 and suppresses myostatin expression in skeletal muscle leading to muscle fiber hypertrophy.
Uniprot IDO70343
Protein Accession #NP_032930.1
Nucleotide Accession #NM_008904.2
Protein Size (# AA)Cys577~Asn766
Molecular Weight24kDa
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