PPAP2A Antibody - C-terminal region (OAAB19279)

Catalog No: OAAB19279

Size:400ul

Anti-PPAP2A Antibody (C-term)at 1: 2000 dilution + human kidney lysates
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution
Predicted band size: 32 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.

Anti-PPAP2A Antibody (C-term)at 1: 1000 dilution + human liver lysates
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution
Predicted band size: 32 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This PPAP2A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 247-281 amino acids from the C-terminal region of human PPAP2A.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Application Info: WB: 1:2000
  WB: 1:1000
• Reference: Kai M.,et al.J. Biol. Chem. 272:24572-24578(1997).
  Leung D.W.,et al.DNA Cell Biol. 17:377-385(1998).
  Ulrix W.E.J.,et al.J. Biol. Chem. 273:4660-4665(1998).
  Roberts R.,et al.J. Biol. Chem. 273:22059-22067(1998).
  Schmutz J.,et al.Nature 431:268-274(2004).
  

Target Info

• Gene Symbol: PPAP2A
• Alias Symbols: LPP1, PAP2, LLP1a, PAP-2a, PPAP2A
• NCBI Gene Id: 8611
• Description of Target: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
• Uniprot ID: O14494
• Molecular Weight: 32 kDa