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POU1F1 antibody - C-terminal region (ARP31419_P050)

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100 ul
$319.00
In Stock

Conjugation Options

ARP31419_P050-FITC Conjugated

ARP31419_P050-HRP Conjugated

ARP31419_P050-Biotin Conjugated

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Gene Symbol:
POU1F1
NCBI Gene Id:
5449
Official Gene Full Name:
POU class 1 homeobox 1
Protein Name:
Pituitary-specific positive transcription factor 1
Swissprot Id:
P28069
Protein Accession #:
NP_000297
Nucleotide Accession #:
NM_000306
Alias Symbols:
PIT1, CPHD1, GHF-1, Pit-1, POU1F1a
Description of Target:
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP.
Protein Size (# AA):
291
Molecular Weight:
33kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express POU1F1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express POU1F1.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human POU1F1
Species Reactivity:
Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 86%
Complete computational species homology data:
Anti-POU1F1 (ARP31419_P050)
Peptide Sequence:
Synthetic peptide located within the following region: QEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
CEBPD; NCOR1; CREBBP; MED1; GATA2; NR1I3; NR1I2; PITX1; JUN; ETS1; NR3C1; VDR; PPARG; PPARA;
Blocking Peptide:
For anti-POU1F1 (ARP31419_P050) antibody is Catalog # AAP31419 (Previous Catalog # AAPP03105)
Datasheets/Manuals:
Printable datasheet for anti-POU1F1 (ARP31419_P050) antibody
Target Reference:
Dattani,M.T., et al., (2003) GrowthHorm.IGFRes.16(9),1207-1209
Publications:

Tennant, D. A. & Gottlieb, E. HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression. J. Mol. Med. (Berl). 88, 839-49 (2010). IHC, WB, Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish 20383689

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