POSTN Antibody - C - terminal region (OAAB08204)

Catalog No: OAAB08204

Size:400ul

POSTN Antibody (C-term) (Cat. #OAAB08204) western blot analysis in MCF-7(lane 1),A375(lane 2) cell line lysates (35ug/lane).This demonstrates the POSTN antibody detected the POSTN protein (arrow).

POSTN Antibody (C-term) (Cat. #OAAB08204)immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of POSTN Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Confocal immunofluorescent analysis of POSTN Antibody (C-term)(Cat#OAAB08204) with A375 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC, IF
• Additional Information: Function: Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization
  Cellular Location: Golgi apparatus (By similarity). Secreted, extracellular space, extracellular matrix. Note=Co-localizes with BMP1 in the Golgi (By similarity)
  Tissue Location: Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This POSTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 687-716 amino acids from the C-terminal region of human POSTN.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Intended Use: POSTN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: FC: 1:25
  WB: 1:1000
  IHC-P: 1:10~50
  IF: 1:10~50

Target Info

• Gene Symbol: POSTN
• Alias Symbols: PN, OSF2, OSF-2, PDLPOSTN
• NCBI Gene Id: 10631
• Protein Name: Periostin
• Description of Target: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q15063
• Protein Accession #: NP_001129406.1
• Molecular Weight: 93314 Da