POLR3D Antibody (OAAF03590)

Catalog No: OAAF03590 (Formerly GWB-ASE543)

Size:100 ug

Click here to learn more about Aviva's By-Request Conjugation Service.

Western blot analysis of extracts from MCF-7 cells, using RPC4 Antibody. The lane on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human RPC4.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: RPC4 antibody detects endogenous levels of total RPC4 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1:3000; ELISA: 1:40000
• Reference: Ittmann M., Mol. Cell. Biol. 7:3386-3393(1987).
  Hu P., Mol. Cell. Biol. 22:8044-8055(2002).
  Kalnine N., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

Target Info

• Gene Symbol: POLR3D
• Gene Full Name: RNA polymerase III subunit D
• Alias Symbols: BN51 (BHK21) temperature sensitivity complementing;BN51T;C53;DNA-directed RNA polymerase III 47 kDa polypeptide;DNA-directed RNA polymerase III subunit D;DNA-directed RNA polymerase III subunit RPC4;polymerase (RNA) III (DNA directed) polypeptide D, 44kDa;polymerase (RNA) III subunit D;Protein BN51;RNA polymerase III 47 kDa subunit;RNA polymerase III subunit C4;RPC4;RPC53;RPC53 homolog;temperature sensitive complementation, cell cycle specific, tsBN51;TSBN51.
• NCBI Gene Id: 661
• Protein Name: DNA-directed RNA polymerase III subunit RPC4
• Description of Target: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
• Uniprot ID: P05423
• Protein Accession #: NP_001713.2
• Molecular Weight: 44 kDa