Size:100 ug
$315.00
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SKU
OACA02433
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More Information
Predicted Species Reactivity Human
Product Format Liquid
Clonality Polyclonal
Isotype IgG
Host Rabbit
Application IHC, CHIP
Reconstitution and Storage Store at 4C for up to one month. For long term storage, aliquot and store at -20C or -80C. Avoid freeze thaw cycles.
Replacement Item This antibody may replace item sc-107058 from Santa Cruz Biotechnology.
Immunogen Recombinant human DNA-directed RNA polymerase III subunit RPC1 protein (392-632AA)
Purification Caprylic Acid Ammonium Sulfate Precipitation purified
Predicted Homology Based on Immunogen Sequence Human
Datasheets/Manuals Printable datasheet for anti-POLR3A (OACA02433) antibody
Specificity Human
Formulation Provided in PBS, pH 7.4, 50% Glycerol, 0.03% Proclin 300
Target Reference [1] Novel compound heterozygous mutations of POLR3A revealed by whole-exome sequencing in a patient with hypomyelination. Shimojima K., Shimada S., Tamasaki A., Akaboshi S., Komoike Y., Saito A., Furukawa T., Yamamoto T. Brain Dev. 36:315-321 (2014).
[2] Mutations in POLR3A and POLR3B are a major cause of hypomyelinating leukodystrophies with or without dental abnormalities and/or hypogonadotropic hypogonadism. Daoud H., Tetreault M., Gibson W., Guerrero K., Cohen A., Gburek-Augustat J., Synofzik M., Brais B., Stevens C.A., Sanchez-Carpintero R., Goizet C., Naidu S., Vanderver A., Bernard G. J. Med. Genet. 50:194-197 (2013).
[3] Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy. Saitsu H., Osaka H., Sasaki M., Takanashi J., Hamada K., Yamashita A., Shibayama H., Shiina M., Kondo Y., Nishiyama K., Tsurusaki Y., Miyake N., Doi H., Ogata K., Inoue K., Matsumoto N. Am. J. Hum. Genet. 89:644-651 (2011).
Gene Symbol POLR3A
Official Gene Full Name polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Alias Symbols ADDH, HLD7, RPC1, RPC155, hRPC155
NCBI Gene Id 11128
Protein Name DNA-directed RNA polymerase III subunit RPC1
Description of Target The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response.
Swissprot Id O14802
Protein Accession # NP_008986.2
Nucleotide Accession # NM_007055.3
Protein Size (# AA) 1390
Molecular Weight 156 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express POLR3A.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express POLR3A.
  1. What is the species homology for "POLR3A Antibody (OACA02433)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "POLR3A Antibody (OACA02433)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "POLR3A Antibody (OACA02433)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "POLR3A Antibody (OACA02433)"?

    This target may also be called "ADDH, HLD7, RPC1, RPC155, hRPC155" in publications.

  5. What is the shipping cost for "POLR3A Antibody (OACA02433)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "POLR3A Antibody (OACA02433)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "POLR3A Antibody (OACA02433)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "156 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "POLR3A Antibody (OACA02433)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "POLR3A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "POLR3A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "POLR3A"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "POLR3A"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "POLR3A"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "POLR3A"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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