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POLR3A Antibody (OACA02433)

100 ug
$315.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
IHC, CHIP
Reconstitution and Storage:
Store at 4C for up to one month. For long term storage, aliquot and store at -20C or -80C. Avoid freeze thaw cycles.
Replacement Item:
This antibody may replace item sc-107058 from Santa Cruz Biotechnology.
Immunogen:
Recombinant human DNA-directed RNA polymerase III subunit RPC1 protein (392-632AA)
Purification:
Caprylic Acid Ammonium Sulfate Precipitation purified
Predicted Homology Based on Immunogen Sequence:
Human
Datasheets/Manuals:
Printable datasheet for anti-POLR3A (OACA02433) antibody
Specificity:
Human
Formulation:
Provided in PBS, pH 7.4, 50% Glycerol, 0.03% Proclin 300
Target Reference:
[1] Novel compound heterozygous mutations of POLR3A revealed by whole-exome sequencing in a patient with hypomyelination. Shimojima K., Shimada S., Tamasaki A., Akaboshi S., Komoike Y., Saito A., Furukawa T., Yamamoto T. Brain Dev. 36:315-321 (2014).
[2] Mutations in POLR3A and POLR3B are a major cause of hypomyelinating leukodystrophies with or without dental abnormalities and/or hypogonadotropic hypogonadism. Daoud H., Tetreault M., Gibson W., Guerrero K., Cohen A., Gburek-Augustat J., Synofzik M., Brais B., Stevens C.A., Sanchez-Carpintero R., Goizet C., Naidu S., Vanderver A., Bernard G. J. Med. Genet. 50:194-197 (2013).
[3] Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy. Saitsu H., Osaka H., Sasaki M., Takanashi J., Hamada K., Yamashita A., Shibayama H., Shiina M., Kondo Y., Nishiyama K., Tsurusaki Y., Miyake N., Doi H., Ogata K., Inoue K., Matsumoto N. Am. J. Hum. Genet. 89:644-651 (2011).
Gene Symbol:
POLR3A
Official Gene Full Name:
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Alias Symbols:
ADDH, HLD7, RPC1, RPC155, hRPC155
NCBI Gene Id:
11128
Protein Name:
DNA-directed RNA polymerase III subunit RPC1
Description of Target:
The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response.
Swissprot Id:
O14802
Protein Accession #:
NP_008986.2
Nucleotide Accession #:
NM_007055.3
Protein Size (# AA):
1390
Molecular Weight:
156 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express POLR3A.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express POLR3A.

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