PML Antibody - middle region (ARP97288_P050)

Catalog No: ARP97288_P050

Host: Rabbit
Target Name: PML
Sample Tissue: Human HepG2 Whole Cell lysates
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PML
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: DGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCD
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-PML (ARP97288_P050) antibody is Catalog # AAP97288

Target Info

• Gene Symbol: PML
• Gene Full Name: promyelocytic leukemia
• Alias Symbols: MYL, RNF71, PP8675, TRIM19
• NCBI Gene Id: 5371
• Protein Name: MYL, RNF71, PP8675, TRIM19
• Description of Target: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Uniprot ID: P29590-12
• Protein Accession #: NP_002666.1
• Nucleotide Accession #: NM_002675.3
• Protein Size (# AA): 585
• Molecular Weight: 64 kDa