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PLK1 cDNA (ANA10299)

1ug
$189.00
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Gene Symbol:
PLK1
NCBI Gene Id:
5347
Description of Target:
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.
Nucleotide Accession #:
BC014846
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PLK1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PLK1.
Tag:
None
Protein Interactions:
RAP1GAP; CHFR; KLHL22; BRCA1; BORA; EGFR; UBC; NUAK1; MUS81; FBXO6; PPP6R2; STK3; BUB1B; FZR1; CDC20; CHEK2; TP53BP1; CDCA5; LATS1; CENPU; CDC25C; KLHL21; OFD1; CUL2; Sugt1; KRBA1; HSPA4; PHC2; KLHL9; FLJ20712; RABAC1; TANK; RBX1; VCP; CDH1; APP; STAG2; N
Reconstitution and Storage:
Centrifuge the vials after receiving and add 5 μl ddH2O
Datasheets/Manuals:
Printable datasheet for anti-PLK1 (ANA10299) antibody

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