PLAU Antibody - C-terminal region (ARP63734_P050)

Catalog No: ARP63734_P050

WB Suggested Anti-PLAU Antibody
Titration: 1.0 ug/ml
Positive Control: Fetal Heart

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Horse, Rabbit, Yeast
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Horse: 86%; Human: 100%; Rabbit: 86%; Yeast: 100%
• Peptide Sequence: Synthetic peptide located within the following region: CSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-PLAU (ARP63734_P050) antibody is Catalog # AAP63734

Target Info

• Gene Symbol: PLAU
• Gene Full Name: Plasminogen activator, urokinase
• Alias Symbols: ATF, QPD, UPA, URK, u-PA, BDPLT5
• NCBI Gene Id: 5328
• Protein Name: Urokinase-type plasminogen activator
• Description of Target: This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
• Uniprot ID: P00749
• Protein Accession #: NP_002649
• Nucleotide Accession #: NM_002658
• Protein Size (# AA): 431
• Molecular Weight: 28kDa
• Protein Interactions: TEX101; UBC; PLAUR; SUMO1; NEDD8; CEBPG; ELAVL1; MYC; BTK; ALAS1; SCAMP5; PDGFC; ST14; SERPINA5; LRP2; SERPINF2; F2; SERPINB2; PLAT; SERPINE1; PLG; SERPINB6; IGF2R; HGF; NID1; CTSL; CTSB; MAP2K1; HRAS; SERPINE2;