Plasminogen Activator Inhibitor 1 Protein (OPRB00075)

Datasheets/Manuals	Printable datasheet for Plasminogen Activator Inhibitor 1 Protein (OPRB00075)

Product Info
Product Format	Liquid
Application	WB
Purity	>95% by SDS-PAGE
Reference	Gils, A & Declerck, P.J. 2004 Curr. Med. Chem. 11 (17) : 2323- 2334.

Gene Symbol	SERPINE1
Alias Symbols	PAI, PAI1, PAI-1, PLANH1
NCBI Gene Id	5054
Protein Name	Plasminogen activator inhibitor 1
Uniprot ID	P05121

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Protein interactions

Biological pathways

Name	# of Products
Angiogenesis	366
Cellular response to chemical stimulus	25
Cellular response to lipopolysaccharide	154
Chronological cell aging	37
Defense response to Gram-negative bacterium	93
Fibrinolysis	96
Negative regulation of apoptotic process	538
Negative regulation of cell adhesion mediated by integrin	30
Negative regulation of fibrinolysis	47
Negative regulation of plasminogen activation	27
Negative regulation of smooth muscle cell migration	59
Negative regulation of smooth muscle cell-matrix adhesion	25
Negative regulation of vascular wound healing	25
Platelet activation	875
Platelet degranulation	443
Positive regulation of angiogenesis	241
Positive regulation of interleukin-8 production	127
Positive regulation of leukotriene production involved in inflammatory response	25
Positive regulation of monocyte chemotaxis	54
Positive regulation of receptor-mediated endocytosis	55
Regulation of receptor activity	37

Biological process

Name	# of Products
Angiogenesis	196
Blood coagulation	396
Cellular response to chemical stimulus	4
Cellular response to gravity	1
Cellular response to lipopolysaccharide	64
Chronological cell aging	3
Defense response to Gram-negative bacterium	23
Fibrinolysis	15
Glucose homeostasis	77
Negative regulation of apoptotic process	356
Negative regulation of blood coagulation	15
Negative regulation of cell adhesion mediated by integrin	3
Negative regulation of cell migration	63
Negative regulation of endopeptidase activity	71
Negative regulation of fibrinolysis	10
Negative regulation of plasminogen activation	5
Negative regulation of smooth muscle cell migration	12
Negative regulation of smooth muscle cell-matrix adhesion	2
Negative regulation of vascular wound healing	1
Negative regulation of wound healing	3
Platelet activation	202
Platelet degranulation	78
Positive regulation of angiogenesis	97
Positive regulation of blood coagulation	14
Positive regulation of inflammatory response	57
Positive regulation of interleukin-8 production	33
Positive regulation of leukotriene production involved in inflammatory response	1
Positive regulation of monocyte chemotaxis	12
Positive regulation of receptor-mediated endocytosis	13
Regulation of receptor activity	14
Response to cytokine stimulus	73
Response to estrogen stimulus	71
Response to glucocorticoid stimulus	109
Response to hyperoxia	20
Response to reactive oxygen species	12
Tissue regeneration	24

Cellular components

Name	# of Products
Extracellular matrix	124
Extracellular region	1573
Extracellular space	884
Plasma membrane	2678
Platelet alpha granule lumen	42
Soluble fraction	338

Protein function

Name	# of Products
Peptidase inhibitor activity	167
Protease binding	376
Protein binding	12191
Receptor binding	932
Serine-type endopeptidase inhibitor activity	229

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