Catalog No: OOMC00008
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OOMC00008
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Datasheets/ManualsPrintable datasheet for OOMC00008
Product Info
Product FormatPowder
Additional InformationCAS: 120685-11-2
Molecular Formula: C35H30N4O4
::Chemical Name: 4’-N-Benzoyl staurosporine
::Primary Activity: Kinase inhibitor (pan specific)
::COVID-19 Rationale: Inhibits MARK2/3, which interact with SARS-CoV-2 Orf9b
Reconstitution and StorageSoluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml). Store at room temperature.
Purity> 98%
Reference1)     Odgerel, et al. (2008) The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations. Oncogene 27 3102 / 2) El Fitori, et al., (2007) PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer Cancer 110 1457 / Miyatake, et al. ( 2007) PKC412 (CGP41251) modulates the proliferation and lipopolysaccharide-induced inflammatory responses of RAW 264.macrophages: Biochem. Biophys. Res. Commun. 360 115 / 4) Bahlis et.al. (2005) N-Benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells Leuk. Lymphoma 46 899 / 5) Fabbro et al., (2000) PKC-412 – a protein kinase inhibitor with a broad therapeutic potential; Anticancer Drug Des. 15 17
Alias SymbolsMidostaurin, CGP-41251
Molecular Weight570.65 g/mol
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