PINK1 Recombinant Protein (OPCD06194)

Catalog No: OPCD06194

PINK1 Recombinant Protein (OPCD06194) using SDS-PAGE

PINK1 Recombinant Protein (OPCD06194) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gly310-Leu566
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Pink1
• Gene Full Name: PTEN induced putative kinase 1
• Alias Symbols: 1190006F07Rik;AU042772;AW557854;br;BRPK;mFLJ00387;PTEN-induced putative kinase protein 1;serine/threonine-protein kinase PINK1, mitochondrial.
• NCBI Gene Id: 68943
• Protein Name: Serine/threonine-protein kinase PINK1, mitochondrial
• Description of Target: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins (PubMed:24652937). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:24784582). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (By similarity). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24784582). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (PubMed:24652937).
• Uniprot ID: Q99MQ3
• Protein Accession #: NP_081156.2
• Nucleotide Accession #: NM_026880.2
• Protein Size (# AA): Gly310~Leu566
• Molecular Weight: 32kDa