Human PIK3R3/PIK3R1/PIK3R2 Antibody : FITC (Phospho-Tyr458/Tyr199) (OAAQ00065)

Catalog No: OAAQ00065

Flow cytometric analysis of Ramos cells stained untreated (red) or treated with pervanadate (green) using phospho-PI3 Kinase p85 (Tyr458)/p55 (Tyr199) antibody PI3KY458-1A11 FITC conjugate. Cat. #OAAQ00065.

Product Info

• Tested Species Reactivity: Human, Mouse
• Predicted Species Reactivity: Mouse, Rat
• Product Format: Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA.
• Clonality: Monoclonal
• Clone: PI3KY458-1A11
• Isotype: Rabbit IgG1k
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: FC
• Reconstitution and Storage: 2-8C
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr458 of human phospho PI3K p85
• Purification: Protein A+G
• Target Post-Translational Modification: Phospho-Tyr458/Tyr199
• Application Info: For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
• Reference: Franke TF, Kaplan DR, and Cantley LC. (1997) Cell. 88: 435-437.
  Fresno JAV, Casado E, Cejas P, et al. (2004) Cancer Treatment Reviews. 30: 193-204.

Target Info

• Gene Symbol: PIK3R3, PIK3R1, PIK3R2
• Gene Full Name: phosphoinositide-3-kinase regulatory subunit 3, phosphoinositide-3-kinase regulatory subunit 1, phosphoinositide-3-kinase regulatory subunit 2
• Alias Symbols: p55, p55PIK, p55-GAMMA
• NCBI Gene Id: 8503; 5295; 5296
• Protein Name: phosphatidylinositol 3-kinase regulatory subunit gamma, phosphatidylinositol 3-kinase regulatory subunit alpha, phosphatidylinositol 3-kinase regulatory subunit beta
• Description of Target: Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity.
  Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.
  Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Three transcript variants, one protein coding and the other two non-protein coding, have been found for this gene.
• Uniprot ID: Q92569, P27986, O00459
• Protein Accession #: NP_001107644.1
• Nucleotide Accession #: NM_001114172.1