Catalog No: OACA10461
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OACA10461
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Datasheets/ManualsPrintable datasheet for PIK3CG Antibody (OACA10461) (OACA10461)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunofluorescence
Reconstitution and Storage-20°C or -80°C
ImmunogenRecombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform protein (438-588AA)
PurificationProtein G Purified
Preservative0.03% Proclin 300
Formulation50% Glycerol, 0.01M PBS, pH 7.4
Purity>95%
Gene SymbolPIK3CG
Gene Full Namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Alias Symbols1-phosphatidylinositol 3-kinase;p110gamma;p120-PI3K;phosphatidylinositol 3 kinase gamma, p110 gamma;phosphatidylinositol 3-kinase catalytic 110-kD gamma;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma;phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform;phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma;Phosphoinositide-3-kinase catalytic gamma polypeptide;phosphoinositide-3-kinase gamma catalytic subunit;PI3CG;PI3K;PI3Kgamma;PI3-kinase subunit gamma;PIK3;ptdIns-3-kinase subunit gamma;ptdIns-3-kinase subunit p110-gamma;serine/threonine protein kinase PIK3CG.
NCBI Gene Id5294
Protein NamePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Description of TargetPhosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Uniprot IDP48736
Protein Accession #NP_001269355
Nucleotide Accession #NM_001282426
  1. What is the species homology for "PIK3CG Antibody (OACA10461)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "PIK3CG Antibody (OACA10461)"?

    This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".

  3. What buffer format is "PIK3CG Antibody (OACA10461)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "PIK3CG Antibody (OACA10461)"?

    This target may also be called "1-phosphatidylinositol 3-kinase;p110gamma;p120-PI3K;phosphatidylinositol 3 kinase gamma, p110 gamma;phosphatidylinositol 3-kinase catalytic 110-kD gamma;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma;phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform;phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma;Phosphoinositide-3-kinase catalytic gamma polypeptide;phosphoinositide-3-kinase gamma catalytic subunit;PI3CG;PI3K;PI3Kgamma;PI3-kinase subunit gamma;PIK3;ptdIns-3-kinase subunit gamma;ptdIns-3-kinase subunit p110-gamma;serine/threonine protein kinase PIK3CG." in publications.

  5. What is the shipping cost for "PIK3CG Antibody (OACA10461)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "PIK3CG Antibody (OACA10461)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "PIK3CG Antibody (OACA10461)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "PIK3CG Antibody (OACA10461)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "PIK3CG"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PIK3CG"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PIK3CG"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PIK3CG"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PIK3CG"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PIK3CG"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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