Catalog No: OACD06494
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SKU
OACD06494
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Datasheets/ManualsPrintable datasheet for PIK3CB Antibody (OACD06494)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ApplicationImmunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Reconstitution and Storage2°C to 8°C|-20°C
ImmunogenRange: Arg321 - Pro507
PurificationAffinity Purified; Protein A Purified
Concentration0.47 mg/ml
Preservative0.02% NaN3
SpecificityThe antibody is a rabbit polyclonal antibody raised against PIK3Cb. It has been selected for its ability to recognize PIK3Cb in immunohistochemical staining and western blotting.
FormulationPBS, pH7.4, containing 0.02% NaN3, 50% glycerol
Application DataWestern blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-1:5,000
Optimal working dilutions must be determined by end user.
Gene SymbolPIK3CB
Gene Full Namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Alias SymbolsP110BETA;phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta;phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform;phosphoinositide-3-kinase, catalytic, beta polypeptide;PI3K;PI3K-beta;PI3KBETA;PI3-kinase p110 subunit beta;PI3-kinase subunit beta;PIK3C1;PtdIns-3-kinase p110;ptdIns-3-kinase subunit beta;ptdIns-3-kinase subunit p110-beta.
NCBI Gene Id5291
Protein NamePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Description of TargetPhosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.
Uniprot IDP42338
  1. What is the species homology for "PIK3CB Antibody (OACD06494)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "PIK3CB Antibody (OACD06494)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: within 1-2 weeks delivery".

  3. What buffer format is "PIK3CB Antibody (OACD06494)" provided in?

    This item is provided in "Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "PIK3CB Antibody (OACD06494)"?

    This target may also be called "P110BETA;phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta;phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform;phosphoinositide-3-kinase, catalytic, beta polypeptide;PI3K;PI3K-beta;PI3KBETA;PI3-kinase p110 subunit beta;PI3-kinase subunit beta;PIK3C1;PtdIns-3-kinase p110;ptdIns-3-kinase subunit beta;ptdIns-3-kinase subunit p110-beta." in publications.

  5. What is the shipping cost for "PIK3CB Antibody (OACD06494)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "PIK3CB Antibody (OACD06494)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "PIK3CB Antibody (OACD06494)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "PIK3CB Antibody (OACD06494)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "PIK3CB"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PIK3CB"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PIK3CB"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PIK3CB"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PIK3CB"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PIK3CB"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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