PI3KgHis Protein (OPPA01186)

Catalog No: OPPA01186 (Formerly GWB-EB2083)

Size:1ug

Product Info

• Product Format: 0.5 mg/ml solution in 25mM HEPES, pH 8.0, 25mM NaCl, 2.5mM MgCl2, and 50% glycerol. Physical appearance: Sterile Filtered clear solution.
• Host: Sf9 Insect Cells
  Biological Activity: ~ 4.5 nmol/mg/min using phosphatidylinositol as the substrate.
  Product Introduction: PI3Kg is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3Kg-/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8a-DCs. In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3Kg.
  Product Description: Recombinant full length PI3Kg (126.3 kDa without Tag) carries an N-terminal His 8 affinity Tag.
• Reconstitution and Storage: PI3Kg although stable at 14C for 1 week, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
• Purity: Greater than 95.0% as determined by SDS-PAGE.

Target Info

• Gene Symbol: PI3Kg His
• Alias Symbols: Phosphoinositide 3-kinase p110g, PI3Kg, PI3KgHis Human, Phosphoinositide 3-kinase p110g Human Recombinant
• Description of Target: Recombinant Human Phosphoinositide 3-kinase p110g