PI 3-kinase p85 Beta Antibody (OAAF05916)

Catalog No: OAAF05916

Size:100 ug

Immunohistochemistry analyzes of PI 3-kinase p85? antibody in paraffin-embedded human brain tissue.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human PI 3-kinase p85beta.
• Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
• Concentration: 1 mg/ml
• Specificity: PI 3-kinase p85beta antibody detects endogenous levels of PI 3-kinase p85beta.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Application Info: IHC: 1:50 - 1:100
  ELISA: 1:10000

Target Info

• Gene Symbol: PIK3R2
• Gene Full Name: phosphoinositide-3-kinase regulatory subunit 2
• Alias Symbols: MPPH;MPPH1;p85;P85B;p85-BETA;phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta;phosphatidylinositol 3-kinase regulatory subunit beta;phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta);phosphoinositide-3-kinase regulatory subunit beta;phosphoinositide-3-kinase, regulatory subunit 2 (beta);PI3K regulatory subunit beta;PI3-kinase subunit p85-beta;ptdIns-3-kinase regulatory subunit p85-beta.
• NCBI Gene Id: 5296
• Protein Name: Phosphatidylinositol 3-kinase regulatory subunit beta
• Description of Target: Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
• Uniprot ID: O00459
• Molecular Weight: 81 kDa