Catalog No: OAAF05913
Size:100 ug
Price: $344.00
SKU
OAAF05913
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for PI 3-kinase p110 Alpha Antibody (OAAF05913)
Product Info
Predicted Species ReactivityHuman, Mouse, Rat
Product FormatLiquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ApplicationELISA, ICC, IF, IHC, IHC-P, WB
Reconstitution and StorageStore at -20°C for 1 year.
ImmunogenThe antiserum was produced against synthesized peptide derived from human PI 3-kinase p110alpha.
PurificationThe antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Concentration1 mg/ml
SpecificityPI 3-kinase p110alpha antibody detects endogenous levels of PI 3-kinase p110alpha.
Application InfoWB: 1:50~200
WB: 1/500 - 1/2000
IHC: 1/100 - 1/300
ELISA: 1/40000
Gene SymbolPIK3CA
Gene Full Namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Alias SymbolsCLAPO;CLOVE;CWS5;MCAP;MCM;MCMTC;mutant phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha;p110-alpha;phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha;phosphatidylinositol 3-kinase, catalytic, alpha polypeptide;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha;phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform;phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha;phosphoinositide 3-kinase alpha;Phosphoinositide-3-kinase catalytic alpha polypeptide;phosphoinositide-3-kinase, catalytic, alpha polypeptide;PI3K;PI3K-alpha;PI3-kinase p110 subunit alpha;ptdIns-3-kinase subunit p110-alpha;serine/threonine protein kinase PIK3CA.
NCBI Gene Id5290
Protein NamePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Description of TargetPhosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).
Uniprot IDP42336
Molecular Weight124 kDa
  1. What is the species homology for "PI 3-kinase p110 Alpha Antibody (OAAF05913)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "PI 3-kinase p110 Alpha Antibody (OAAF05913)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "PI 3-kinase p110 Alpha Antibody (OAAF05913)" provided in?

    This item is provided in "Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "PI 3-kinase p110 Alpha Antibody (OAAF05913)"?

    This target may also be called "CLAPO;CLOVE;CWS5;MCAP;MCM;MCMTC;mutant phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha;p110-alpha;phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha;phosphatidylinositol 3-kinase, catalytic, alpha polypeptide;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha;phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform;phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha;phosphoinositide 3-kinase alpha;Phosphoinositide-3-kinase catalytic alpha polypeptide;phosphoinositide-3-kinase, catalytic, alpha polypeptide;PI3K;PI3K-alpha;PI3-kinase p110 subunit alpha;ptdIns-3-kinase subunit p110-alpha;serine/threonine protein kinase PIK3CA." in publications.

  5. What is the shipping cost for "PI 3-kinase p110 Alpha Antibody (OAAF05913)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "PI 3-kinase p110 Alpha Antibody (OAAF05913)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "PI 3-kinase p110 Alpha Antibody (OAAF05913)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "124 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "PI 3-kinase p110 Alpha Antibody (OAAF05913)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "PIK3CA"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PIK3CA"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PIK3CA"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PIK3CA"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PIK3CA"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PIK3CA"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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