PHOX2B Antibody - C-terminal region : FITC (ARP74127_P050-FITC)

Catalog No: ARP74127_P050-FITC

Size:100ul

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Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PHX2B
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: RAAAAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-PHOX2B (ARP74127_P050-FITC) antibody is Catalog # AAP74127

Target Info

• Gene Symbol: PHOX2B
• Gene Full Name: paired like homeobox 2B
• Alias Symbols: CCHS, PMX2B, NBLST2, NBPhox
• NCBI Gene Id: 8929
• Protein Name: paired mesoderm homeobox protein 2B
• Description of Target: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.
• Uniprot ID: Q99453
• Protein Accession #: NP_003915
• Protein Size (# AA): 314
• Molecular Weight: 34kDa
• Protein Interactions: UBC;