Size:100ug
$315.00
Discontinued
SKU
OASE00084
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Phosphotyrosine Antibody (OASE00084)

Catalog#: OASE00084
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More Information
Predicted Species Reactivity Not species specific
Clonality Monoclonal
Clone 13F9
Isotype IgG1 Kappa
Host Mouse
Application WB
Additional Information Background Info: Reacts with phosphotyrosine, and detects the presence of phosphotyrosine in both un-stimulated and stimulated cell lysates. Does not cross-react with phosphoserine or phosphothreonine.
:: Scientific Background: Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a protein's activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine; others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time (1). Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders (2-4).
In particular, the phosphorylation of tyrosine is considered one of the key steps in signal transduction and regulation of enzymatic activity (5). Phosphotyrosine can be detected through specific antibodies, and are helpful in facilitating the identification of tyrosine kinase substrates (6).
Reconstitution and Storage Store at -20C. Shipping in Blue Ice or 4C.
Immunogen Phosphotyrosine conjugated to KLH
Purification Ascites
Concentration 1mg/mL
Datasheets/Manuals Printable datasheet for OASE00084
Dilution 1:2000 to 1:10000
Storage Buffer Ascites
Target Reference 1. Goto H. et al. (2005) Nature Cell Biology 8: 180-187. 2. Blume-Jensen P. and Hunter T. (2001) Nature 411:355-365.
3. Downward J. (2001) Nature 411: 759-762.
4. Pawson T. and Saxton T.M. (1999) Cell 97: 675-678.
5. Frackelton A.R. Jr., Ross A.H., and Eisen H.N. (1983) Mol
Cell Biol. 3: 1343-1352.
6. Ross A.H., Baltimore D., and Eisen H.N. (1981) Nature 294:
654-656.
7. Ostrovsky PC. (1995) Genes Dev. 9(16): 2034-2041.
  1. What is the species homology for "Phosphotyrosine Antibody (OASE00084)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Not species specific".

  2. How long will it take to receive "Phosphotyrosine Antibody (OASE00084)"?

    This item is available "Domestic: within 3-5 days delivery | International: 3-5 days".

  3. What buffer format is "Phosphotyrosine Antibody (OASE00084)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Phosphotyrosine Antibody (OASE00084)"?

    This target may also be called "" in publications.

  5. What is the shipping cost for "Phosphotyrosine Antibody (OASE00084)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Phosphotyrosine Antibody (OASE00084)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Phosphotyrosine Antibody (OASE00084)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Phosphotyrosine Antibody (OASE00084)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for ""?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for ""?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with ""?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with ""?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with ""?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with ""?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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