PHLDA2 Protein (OPPA01863)

Catalog No: OPPA01863 (Formerly GWB-2AD9EC)

Size:2UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: PHLDA2 solution containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol 0.1M NaCl and 1mM DTT. Physical appearance: Sterile filtered colorless solution.
• Host: E. Coli
  Product Introduction: Pleckstrin homology-like domain family A member 2 (PHLDA2) is a cytoplasmic protein, which is involved in fetal and placental growth. PHLDA2 is an apoptosis-related protein, which acts as a negative growth regulator and is expressed during normal human development. PHLDA2 is imprinted on placenta, liver and fetal tissues during embryogenesis and is removed once development is complete. The PHLDA2 gene is one of a number of genes in the imprinted gene domain of 11p15.5 which is considered to be an important tumor suppressor gene region. Changes in this region may be linked to the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. PHLDA2 is expressed in placenta (present in all cells of the villous cytotrophoblast) and adult prostate gland. Furthermore, PHLDA2 is expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines and at low levels in adult liver and lung, and fetal liver.
  Product Description: PHLDA2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids (1-152 a.a.) and having a molecular mass of 19.2 kDa. PHLDA2 is fused to 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
• Reconstitution and Storage: PHLDA2 Human Recombinant although stable at 4C for 1 week, should be stored below -18C. Please prevent freeze thaw cycles.
• Purity: Greater than 80% as determined by SDS-PAGE.
• Peptide Sequence: MGSSHHHHHH SSGLVPRGSH MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF RSRQERTAPA APAEDAVAAA AAAPSEPSEP SRPSPQPKPR TP.

Target Info

• Gene Symbol: PHLDA2
• Alias Symbols: IPL, BRW1C, BWR1C, HLDA2, TSSC3
• NCBI Gene Id: 7262
• Protein Name: Pleckstrin homology-like domain family A member 2
• Description of Target: Recombinant Human Pleckstrin Homology-Like Domain Family A Member 2
• Uniprot ID: Q53GA4
• Protein Accession #: NP_003302.1
• Protein Size (# AA): Recombinant