PHB Antibody - C-terminal region : FITC (ARP32807_P050-FITC)

Catalog No: ARP32807_P050-FITC

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: WB, IHC
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PHB
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
• Peptide Sequence: Synthetic peptide located within the following region: AEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-PHB (ARP32807_P050-FITC) antibody is Catalog # AAP32807 (Previous Catalog # AAPP03826)
• Sample Type Confirmation:

  PHB is supported by BioGPS gene expression data to be expressed in Jurkat

• Reference: Fraering,P.C., et al., (2004) Biochemistry 43 (30), 9774-9789

Target Info

• Gene Symbol: PHB
• Gene Full Name: Prohibitin
• Alias Symbols: PHB1, HEL-215, HEL-S-54e
• NCBI Gene Id: 5245
• Protein Name: Prohibitin
• Description of Target: Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
• Uniprot ID: P35232
• Protein Accession #: NP_002625
• Nucleotide Accession #: NM_002634
• Protein Size (# AA): 272
• Molecular Weight: 30kDa
• Protein Interactions: FUS; HUWE1; SUMO2; SPRTN; STAU1; MDM2; SUZ12; EED; RNF2; PARP1; NAP1L1; COX6C; LONRF3; FBXO6; ADRB2; HDAC5; RAF1; KRAS; RAPH1; IPO11; SMG5; YWHAZ; YWHAB; VDAC2; RPS4X; RPL7; PRKCD; PLEC; NPM1; LMNA; IGHG1; HSP90AB1; GTF3C1; DBN1; COL9A2; CAPZA1; SLC25A5;