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PHB Antibody - C-terminal region (ARP32807_P050)

100 ul
$289.00
In Stock
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Conjugation Options

ARP32807_P050-FITC Conjugated

ARP32807_P050-HRP Conjugated

ARP32807_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB, IHC
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
PHB
Official Gene Full Name:
Prohibitin
NCBI Gene Id:
5245
Protein Name:
Prohibitin
Swissprot Id:
P35232
Protein Accession #:
NP_002625
Nucleotide Accession #:
NM_002634
Alias Symbols:
PHB1
Replacement Item:
This antibody may replace item sc-56346 from Santa Cruz Biotechnology.
Description of Target:
Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
Protein Size (# AA):
272
Molecular Weight:
30kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PHB.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PHB.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human PHB
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Complete computational species homology data:
Anti-PHB (ARP32807_P050)
Peptide Sequence:
Synthetic peptide located within the following region: AEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLS
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
FUS; HUWE1; SUMO2; SPRTN; STAU1; MDM2; SUZ12; EED; RNF2; PARP1; NAP1L1; COX6C; LONRF3; FBXO6; ADRB2; HDAC5; RAF1; KRAS; RAPH1; IPO11; SMG5; YWHAZ; YWHAB; VDAC2; RPS4X; RPL7; PRKCD; PLEC; NPM1; LMNA; IGHG1; HSP90AB1; GTF3C1; DBN1; COL9A2; CAPZA1; SLC25A5;
Blocking Peptide:
For anti-PHB (ARP32807_P050) antibody is Catalog # AAP32807 (Previous Catalog # AAPP03826)
Datasheets/Manuals:
Printable datasheet for anti-PHB (ARP32807_P050) antibody
Sample Type Confirmation:

PHB is supported by BioGPS gene expression data to be expressed in Jurkat

Target Reference:
Fraering,P.C., et al., (2004) Biochemistry 43 (30), 9774-9789

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