PECAM1 Antibody (OABF00161)

Catalog No: OABF00161

Size:100UL

Formalin-fixed and paraffin embedded rat skin tissue labeled with Anti-CD31/PECAM-1 Polyclonal Antibody, Unconjugated (OABF00161) at 1:300, followed by conjugation to the secondary antibody and DAB staining

Formalin-fixed: Endothelial cells labeled with Anti-CD31/PECAM-1 Polyclonal Antibody, Unconjugated (OABF00161) at 1:200, followed by conjugation to the secondary antibody was Goat Anti-Rabbit IgG, FITC conjugated at 1:200 for 40 minutes at 37

Product Info

• Predicted Species Reactivity: Dog|Horse|Human|Mouse|Porcine|Rabbit|Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location: Cytoplasm
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from mouse CD31
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  FC: 1:20 - 100
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: PECAM1
• Gene Full Name: platelet and endothelial cell adhesion molecule 1
• Alias Symbols: CD31;CD31 antigen;CD31/EndoCAM;endoCAM;GPIIA';PECA1;PECAM-1;platelet endothelial cell adhesion molecule;platelet endothelial cell adhesion molecule-1.
• NCBI Gene Id: 5175
• Protein Name: Platelet endothelial cell adhesion molecule
• Description of Target: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity).
• Uniprot ID: P16284