PEBP1 Protein (OPPA02208)

Catalog No: OPPA02208 (Formerly GWB-1FAEA4)

Size:10UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: The PEBP1 protein solution contains 20mM Tris-HCl buffer (pH8.0), 1mM DTT and 10% glycerol. Physical appearance: Sterile Filtered colorless solution.
• Host: E. coli
  Product Introduction: PEBP1 (Phosphatidylethanolamine binding protein 1) belongs to the phosphatidylethanolamine-binding protein family and a serine protease inhibitor that inhibits thrombin, neuropsin. PEBP1 plays a key modulatory part in several protein kinase signaling cascades. PKC phosphorylates PEBP1, resulting in the release of Raf-1 and activation of MEK and ERK. PEBP1 is expressed in many tissues and implicated in the regulation of such physiological processes as membrane biosynthesis, spermatogenesis, neural development, and metastasis suppression.PEBP1 binds ATP, opioids and phosphatidylethanolamine, however it has lower affinity for phosphatidylinositol and phosphatidylcholine. PEBP1 may also be involved in the function of the presynaptic cholinergic neurons of the CNS. PEBP1 increases the production of choline acetyltransferase although not acetylcholinesterase. Furtheremore, PEBP1 functions in potentially sequestering toxic compounds, including locostatin which may have harmful effects on cells.Loss of PEBP1 expression may have a significant role as prognostic marker in Gastrointestinal stromal tumors. In addition, PEBP1 is found differentially expressed in the Wernicke's Area from schizophrenia patients. PEBP1 is also, an invasion suppressor protein in nasopharyngeal carcinoma.
  Product Description: PEBP1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 187 amino acids (1-187 a.a.) and having a molecular mass of 21kDa.The PEBP1 is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: Store at 4C if entire vial will be used within 2-4 weeks. Store frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Peptide Sequence: MPVDLSKWSG PLSLQEVDEQ PQHPLHVTYA GAAVDELGKV LTPTQVKNRP TSISWDGLDS GKLYTLVLTD PDAPSRKDPK YREWHHFLVV NMKGNDISSG TVLSDYVGSG PPKGTGLHRY VWLVYEQDRP LKCDEPILSN RSGDHRGKFK VASFRKKYEL RAPVAGTCYQ AEWDDYVPKL YEQLSGK.

Target Info

• Gene Symbol: PEBP1
• Alias Symbols: PBP, HCNP, PEBP, RKIP, HCNPpp, PEBP-1, HEL-210, HEL-S-34, HEL-S-96
• NCBI Gene Id: 5037
• Protein Name: Phosphatidylethanolamine-binding protein 1
• Description of Target: Recombinant Human Phosphatidylethanolamine Binding Protein 1 (PEBP1) produced in E.coli is a single, non-glycosylated, polypeptide chain containing 187 amino acids (1-187 a.a.) and having a molecular mass of 21kDa.The PEBP1 is purified by proprietary chromatographic techniques.
• Uniprot ID: P30086
• Protein Accession #: NP_002558.1
• Protein Size (# AA): Recombinant