PDGFRA Antibody (Phospho-Tyr762) (OASG05741)

Catalog No: OASG05741

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human PDGFR- Alpha around the phosphorylation site of Y762. Location: 700-780aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Tyr762
• Specificity: Phospho-PDGFR- Alpha (Tyr762) Polyclonal Antibody detects endogenous levels of PDGFR- Alpha protein only when phosphorylated at Y762.
• Application Info: IHC 1:100-1:300; ELISA 1:10000;

Target Info

• Gene Symbol: PDGFRA
• Gene Full Name: platelet-derived growth factor receptor, alpha polypeptide
• Alias Symbols: CD140A, PDGFR2, PDGFR-2
• NCBI Gene Id: 5156; 18595; 25267
• Description of Target: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
• Uniprot ID: P16234, P26618, P20786
• Molecular Weight: 85 kDa