PDE6D Protein (OPPA02164)

Catalog No: OPPA02164 (Formerly GWB-387D65)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: The PDE6D protein solution contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 1mM DTT and 100mM NaCl. Physical appearance: Sterile filtered colorless solution.
• Host: E. Coli
  Product Introduction: Human PDE6D was initially identified as a fourth subunit of rod-specific cGMP phosphodiesterase, PDE6. PDE6D is an Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain. PDE6D interacts with RPGR, ARL2 and ARL3. The catalytically active PDE6 is a heterodimer (alphabeta) that is controlled by two inhibitory gamma subunits. Since PDE6D does not change the catalytic properties of PDEalphabeta, its function is still unanswered. PDE6D is expressed specifically in the retina.
  Product Description: PDE6D produced in E.Coli is a single, non-glycosylated polypeptide chain containing 158 amino acids (1-150 a.a.) and having a molecular mass of 18.4kDa. PDE6D is fused to 8 amino acids His Tag at C-terminus and purified by proprietary chromatographic techniques.
• Reconstitution and Storage: Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Avoid multiple freeze-thaw cycles.
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Peptide Sequence: MSAKDERARE ILRGFKLNWM NLRDAETGKI LWQGTEDLSV PGVEHEARVP KKILKCKAVS RELNFSSTEQ MEKFRLEQKV YFKGQCLEEW FFEFGFVIPN STNTWQSLIE AAPESQMMPA SVLTGNVIIE TKFFDDDLLV STSRVRLFYV GSHHHHHH.

Target Info

• Gene Symbol: PDE6D
• Alias Symbols: PDED, JBTS22
• NCBI Gene Id: 5147
• Protein Name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
• Description of Target: Recombinant Human Phosphodiesterase 6D cGMP-Specific Rod Delta
• Uniprot ID: O43924
• Protein Accession #: NP_002592.1
• Protein Size (# AA): Recombinant