PDE12 Antibody - middle region (ARP53350_P050)

Catalog No: ARP53350_P050

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Host: Rabbit
Target Name: PDE12
Sample Tissue: Human Jurkat
Antibody Dilution: 1.0ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human 2'-PDE
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: CLDYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKW
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-PDE12 (ARP53350_P050) antibody is Catalog # AAP53350 (Previous Catalog # AAPP30933)
• Sample Type Confirmation:

  PDE12 is supported by BioGPS gene expression data to be expressed in OVCAR3

Target Info

• Reference: Kubota,K., (2004) J. Biol. Chem. 279 (36), 37832-37841
• Gene Symbol: PDE12
• Gene Full Name: Phosphodiesterase 12
• Alias Symbols: 2-PDE, 2'-PDE
• NCBI Gene Id: 201626
• Protein Name: 2',5'-phosphodiesterase 12
• Description of Target: 2'-PDE is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2'-PDE also cleaves 3',5'-phosphodiester bond of oligoadenylates. 2'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
• Uniprot ID: Q6L8Q7
• Protein Accession #: NP_808881
• Nucleotide Accession #: NM_177966
• Protein Size (# AA): 609
• Molecular Weight: 67kDa
• Protein Interactions: SUMO2; SUMO1; UBC; NEDD8; DCTPP1; NPLOC4; UBQLN2; EHD1; WDR4; PDLIM5; SAE1; UBA2; CUL5; XPNPEP1; STAT6; RAD23B; PGGT1B; DNAJB1; ADSL; APEX2; COPS5; CUL3; UBL4A;