PDCD6IP Recombinant Protein (OPCD06049)

Catalog No: OPCD06049

PDCD6IP Recombinant Protein (OPCD06049) using SDS-PAGE

PDCD6IP Recombinant Protein (OPCD06049) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Lys239
  Subcellular Location: Cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Pdcd6ip
• Gene Full Name: programmed cell death 6 interacting protein
• Alias Symbols: A;AI480591;Aip1;Alg2-interacting protein 1;ALG-2-interacting protein 1;Alg2-interacting protein X;ALG-2-interacting protein X;Alix;AW544830;C76364;E2f1-inducible protein;Eig2;mKIAA1375;programmed cell death 6-interacting protein.
• NCBI Gene Id: 18571
• Protein Name: Programmed cell death 6-interacting protein
• Description of Target: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (By similarity). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (PubMed:27336173).
• Uniprot ID: Q9WU78
• Protein Accession #: NP_001158149.1
• Nucleotide Accession #: NM_001164677.1
• Protein Size (# AA): Met1~Lys239
• Molecular Weight: 32kDa