PDCD1 Antibody : APC (OATA00081)

Catalog No: OATA00081

Human PBMC were stimulated for 3 days with PHA and stained with 5 uL (1 ug) APC Anti-Human CD279 (OATA00081) (solid line) or 1 ug APC Mouse IgG1 isotype control (dashed line).

Product Info

• Tested Species Reactivity: Human
• Product Format: Liquid. 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
• Clonality: Monoclonal
• Clone: J110
• Isotype: Mouse IgG1
• Host: Mouse
• Conjugation: APC: Allophycocyanin
• Application: FC
  Excitation Laser: Red (633-640 nm)
  Emmision: 660 nm
• Reconstitution and Storage: 2-8C protected from light
• Specificity: CD279 (PD-1)
• Application Info: This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. It is recommended to store the product undiluted at 4C, and protected from prolonged exposure to light. Do not freeze.
• Reference:

  Freeman GJ, Long AJ, Iwai Y, et al. 2000. J Exp Med. 192:1027-1034.

  Latchman Y, Wood CR, Chernova T, et al. 2001. Nat Immunol. 2(3):261-268.

  Bennett F, Luxenberg D, Ling V, et al. 2003. J Immunol. 170(2):711-718.

Target Info

• Gene Symbol: PDCD1
• Gene Full Name: programmed cell death 1
• Alias Symbols: PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1
• NCBI Gene Id: 5133
• Protein Name: programmed cell death protein 1
• Description of Target: This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.