Catalog No: ARP40630_T100
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ARP40630_T100
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Datasheets/ManualsPrintable datasheet for anti-PCBP1 (ARP40630_T100) antibody
Product Info
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human PCBP1
PurificationProtein A purified
Predicted Homology Based on Immunogen SequenceCow: 93%; Dog: 92%; Guinea Pig: 93%; Horse: 93%; Human: 93%; Mouse: 93%; Rabbit: 93%; Rat: 93%
Peptide SequenceSynthetic peptide located within the following region: CSDAVGYPHATHDLEGPPLDAYSIQGQHTISPLDLAKLNQVARQQSHFAM
Concentration1.0 mg/ml
Blocking PeptideFor anti-PCBP1 (ARP40630_T100) antibody is Catalog # AAP40630 (Previous Catalog # AAPP10617)
Sample Type Confirmation

PCBP1 is supported by BioGPS gene expression data to be expressed in HepG2

ReferenceZhong,N., (2005) Biochem. Biophys. Res. Commun. 338 (2), 855-861
Gene SymbolPCBP1
Gene Full NamePoly(rC) binding protein 1
Alias SymbolsHNRPX, HNRPE1, hnRNP-X, HEL-S-85, hnRNP-E1
NCBI Gene Id5093
Protein NamePoly(rC)-binding protein 1
Description of TargetPCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
Uniprot IDQ15365
Protein Accession #NP_006187
Nucleotide Accession #NM_006196
Protein Size (# AA)356
Molecular Weight39kDa
Protein InteractionsHUWE1; UBC; SNRPA; TP53; SUMO2; SUMO3; TUBGCP3; STAU1; ERG; EED; TUBB6; TUBB2A; PFKP; PFKM; SRPK2; SRPK1; SRPK3; FBXO6; TARDBP; UBD; ADRB2; NPM1; LMNA; HMGA1; CD81; PAN2; PRPF8; PPIG; PRPF3; UBL4A; ANP32A; VCAM1; NOS2; ITGA4; FN1; ATF2; ZNF830; ZCCHC10; P
  1. What is the species homology for "PCBP1 Antibody - middle region (ARP40630_T100)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit".

  2. How long will it take to receive "PCBP1 Antibody - middle region (ARP40630_T100)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "PCBP1 Antibody - middle region (ARP40630_T100)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "PCBP1 Antibody - middle region (ARP40630_T100)"?

    This target may also be called "HNRPX, HNRPE1, hnRNP-X, HEL-S-85, hnRNP-E1" in publications.

  5. What is the shipping cost for "PCBP1 Antibody - middle region (ARP40630_T100)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "PCBP1 Antibody - middle region (ARP40630_T100)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "PCBP1 Antibody - middle region (ARP40630_T100)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "39kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "PCBP1 Antibody - middle region (ARP40630_T100)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "PCBP1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PCBP1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PCBP1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PCBP1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PCBP1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PCBP1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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