Apoptosis pathway

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Apoptosis is the process of cell death, which may include shrinking of the cell, loss of cell membrane,  fragmentation of the nucleus, and chromosomal DNA fragmentation. The process is controlled by many extracellular signals such as toxins, cytokines, growth factors, and hormones.[1]
1. Elmore, Susan. (2007) “Apoptosis: A Review of Programmed Cell Death”. Toxicol Pathol. Vol. 35 no. 4 495-516.

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TRAIL IL-1 TNFR1 FADD TRAIL-R FADD FADD FADD TRADD MyD88 IRAK PI3K NIK FLIP IKK Akt/PKB PKA Cn Bcl-2/XL IkBa NF-KB CASP3 Bad Bad RIP1 TRADD TRADD DFF45 DFF40 Bcl-XL Bcl-2 Bax CASP3 AIF ENDO-G P53 CASP3 TP53 ENDOG ENDOD1 EXOG AIFM1 DFFA FASLG TNFa NGF IL-3 TrkA IL-IR Bid CytC IAP CASP7 IAP CASP12 ATM Apaf-1 ?q=OASA06980 TRAF2 TRAF2

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