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Catalog No: OAAB16324 (Formerly GWB-U4R6CW)
Size:400ul
Price: $450.00
SKU
OAAB16324
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OAAB16324
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationDB
Additional InformationFunction: Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly (ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production
Cellular Location: Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage.
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T368 of human PARP1.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Application InfoDB: 1:500
ReferenceMajewski, P.M., et al. J. Biol. Chem. 285(45):34828-34838(2010)
Kim, M., et al. Cancer Sci. 101(11):2436-2442(2010)
Dong, Y., et al. Cancer Res. 70(20):8088-8096(2010)
Krishnakumar, R., et al. Mol. Cell 39(5):736-749(2010)
Lee, K.A., et al. Rheumatol. Int. (2010) In press :
Gene SymbolPARP1
Alias SymbolsPARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1
NCBI Gene Id142
Protein NamePoly [ADP-ribose] polymerase 1
Description of TargetThis gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Uniprot IDP09874
Protein Accession #NP_001609.2
Molecular Weight113 kDa
  1. What is the species homology for "PARP1 Antibody (Phospho-Thr368) (OAAB16324)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "PARP1 Antibody (Phospho-Thr368) (OAAB16324)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "PARP1 Antibody (Phospho-Thr368) (OAAB16324)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "PARP1 Antibody (Phospho-Thr368) (OAAB16324)"?

    This target may also be called "PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1" in publications.

  5. What is the shipping cost for "PARP1 Antibody (Phospho-Thr368) (OAAB16324)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "PARP1 Antibody (Phospho-Thr368) (OAAB16324)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "PARP1 Antibody (Phospho-Thr368) (OAAB16324)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "113 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "PARP1 Antibody (Phospho-Thr368) (OAAB16324)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "PARP1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PARP1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PARP1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PARP1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PARP1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PARP1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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