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PARP1 Antibody (OABF00920)

100 ul
$359.00
In Stock
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Conjugation Options

OABF00920-FITC Conjugated

OABF00920-HRP Conjugated

OABF00920-Biotin Conjugated

Gene Symbol:
PARP1
Official Gene Full Name:
poly (ADP-ribose) polymerase 1
NCBI Gene Id:
142
Swissprot Id:
P09874
Alias Symbols:
PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1,
Replacement Item:
This antibody may replace item sc-136208 from Santa Cruz Biotechnology.
Description of Target:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Purified by Protein A.
Application:
WB, IHC-P
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PARP1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PARP1.
Immunogen:
KLH conjugated synthetic peptide derived from human PARP1
Predicted Species Reactivity:
Human, Rat
Product Format:
Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
Reconstitution and Storage:
Store at -20C for 12 months.
Concentration:
1ug/ul
Datasheets/Manuals:
Printable datasheet for OABF00920
Conjugation:
Unconjugated
Isotype:
IgG
Application Info:
WB: 1:100 - 1000
IHC-P: : 1:100 - 500
Additional Information:
Subcellular location: Nucleus

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