PARK2 Antibody (Phospho-Ser131) (OASG05678)

Catalog No: OASG05678

Size:100 uL

Western Blot using 293T, AD293, HeLa,

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human Parkin around the phosphorylation site of S131. Location: 70-150aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Ser131
• Specificity: Phospho-Parkin (S131) Polyclonal Antibody detects endogenous levels of Parkin protein only when phosphorylated at S131.
• Application Info: IHC 1:100-1:300; ELISA 1:20000;

Target Info

• Gene Symbol: PARK2
• Gene Full Name: parkin RBR E3 ubiquitin protein ligase
• Alias Symbols: PDJ, AR-JP, LPRS2, PARK2
• NCBI Gene Id: 5071;
• Description of Target: The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
• Uniprot ID: O60260
• Molecular Weight: 55 kDa