PARD3 Antibody (OACA05370)

Catalog No: OACA05370

Immunohistochemistry of paraffin-embedded human testis at dilution 1:100

Immunohistochemistry of paraffin-embedded human testis at dilution 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Western blot
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Partitioning defective 3 homolog protein (1068-1356AA)
• Purification: Protein G Purified
• Preservative: 0.03% Proclin 300
• Formulation: 50% Glycerol, 0.01M PBS, PH 7.4
• Reference: [1]"Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties."Gao L., Macara I.G., Joberty G.Gene 294:99-107(2002). [2]"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J.Nature 429:375-381(2004). [3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14:2121-2127(2004).

Target Info

• Gene Symbol: PARD3
• Gene Full Name: par-3 family cell polarity regulator
• Alias Symbols: ASIP;atypical PKC isotype-specific interacting protein;Atypical PKC isotype-specific-interacting protein;Baz;bazooka;CTCL tumor antigen se2-5;PAR3;par-3 family cell polarity regulator alpha;par-3 partitioning defective 3 homolog;PAR3alpha;PAR3-alpha;PARD-3;PARD3A;partitioning defective 3 homolog;PPP1R118;protein phosphatase 1, regulatory subunit 118;SE2-5L16;SE2-5LT1;SE2-5T2.
• NCBI Gene Id: 56288
• Protein Name: Partitioning defective 3 homolog
• Description of Target: Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688).
• Uniprot ID: Q8TEW0
• Protein Accession #: NP_001171714
• Nucleotide Accession #: NM_001184785