PAICS Antibody - N-terminal region : HRP (ARP46049_P050-HRP)

Catalog No: ARP46049_P050-HRP

Size:100ul

Click here to learn more about Aviva's By-Request Conjugation Service.

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: HRP: Horseradish Peroxidase
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PAICS
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 93%
• Peptide Sequence: Synthetic peptide located within the following region: ATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-PAICS (ARP46049_P050-HRP) antibody is Catalog # AAP46049 (Previous Catalog # AAPP26890)
• Reference: Beausoleil,S.A., (2006) Nat. Biotechnol. 24 (10), 1285-1292

Target Info

• Gene Symbol: PAICS
• Gene Full Name: Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
• Alias Symbols: ADE2, AIRC, PAIS, ADE2H1
• NCBI Gene Id: 10606
• Protein Name: Multifunctional protein ADE2
• Description of Target: PAICS is a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
• Uniprot ID: P22234
• Protein Accession #: NP_001072992
• Nucleotide Accession #: NM_001079524
• Protein Size (# AA): 425
• Molecular Weight: 47kDa
• Protein Interactions: L3MBTL2; PAICS; HUWE1; UBC; FUS; WWOX; QRICH1; SWAP70; FARSB; SUPT5H; SET; PRKCSH; FXR2; NUDT18; SMARCD1; PRKAG1; FN1; NIF3L1; TP53BP1; UNK; GINS4; TMEM177; RPAP1; SSSCA1; TACC3; STUB1; PUM1; ZPR1; UBE2B; TTC1; NDUFV1; GART; UBD; CUL3; CDK2; TERF1; SIRT7;