Catalog No: OPCD05958
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OPCD05958
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Datasheets/ManualsPrintable datasheet for PAG1 Recombinant Protein (OPCD05958)
Product Info
Predicted Species ReactivityRat|Rattus norvegicus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationCtrl (+), SDS-PAGE, WB
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Ile138-Phe357
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolPag1
Gene Full Namephosphoprotein membrane anchor with glycosphingolipid microdomains 1
Alias SymbolsCbp;Csk binding protein;csk-binding protein;phosphoprotein associated with glycosphingolipid microdomains 1;phosphoprotein associated with glycosphingolipid-enriched microdomains 1;transmembrane phosphoprotein Cbp.
NCBI Gene Id64019
Protein NamePhosphoprotein associated with glycosphingolipid-enriched microdomains 1
Description of TargetNegatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Uniprot IDQ9JM80
Protein Accession #NP_071589.1
Nucleotide Accession #NM_022253.1
Protein Size (# AA)Ile138~Phe357
Molecular Weight25kDa
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