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PABPN1 Antibody - middle region (ARP88148_P050)

100 ul
$289.00
In Stock
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Gene Symbol:
PABPN1
Official Gene Full Name:
poly(A) binding protein, nuclear 1
NCBI Gene Id:
8106
Protein Name:
polyadenylate-binding protein 2
Swissprot Id:
Q86U42-2
Protein Accession #:
NP_004634.1
Nucleotide Accession #:
NM_004643.3
Alias Symbols:
OPMD, PAB2, PABII, PABP2, PABP-2
Description of Target:
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
Protein Size (# AA):
296
Molecular Weight:
31 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PABPN1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PABPN1.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human PABPN1
Predicted Species Reactivity:
Human
Tested Species Reactivity:
Human
Peptide Sequence:
Synthetic peptide located within the following region: LLLEPEPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEGDP
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide:
For anti-PABPN1 (ARP88148_P050) antibody is Catalog # AAP88148
Datasheets/Manuals:
Printable datasheet for anti-PABPN1 (ARP88148_P050) antibody

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