Catalog No: OPCD05946
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OPCD05946
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PA2G4 Recombinant Protein (OPCD05946)

Datasheets/ManualsPrintable datasheet for PA2G4 Recombinant Protein (OPCD05946)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Ser2-Asp394
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolPA2G4
Gene Full Nameproliferation-associated 2G4
Alias Symbolscell cycle protein p38-2G4 homolog;EBP1;ErbB-3 binding protein 1;ErbB-3 receptor binding protein;erbB3-binding protein 1;ErbB3-binding protein Ebp1;HG4-1;p38-2G4;proliferation-associated 2G4, 38kD;proliferation-associated 2G4, 38kDa;proliferation-associated protein 2G4.
NCBI Gene Id5036
Protein NameProliferation-associated protein 2G4
Description of TargetMay play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).
Uniprot IDQ9UQ80
Protein Accession #NP_006182.2
Nucleotide Accession #NM_006191.2
Protein Size (# AA)Ser2~Asp394
Molecular Weight47kDa
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